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POTS and Orthostatic Intolerance: By facilitating the livers clearance of circulating histamine, glutathione reduces inappropriate vasodilation and blood pooling, helping to stabilize blood pressure and reduce the compensatory rapid heart rate associated with dysautonomia

doi: 10.1038/s41586-020-2668-z 18 WilkinsonNPantopoulosK

The authors reported that in obese mice, daily AOD-9604 administration over 14 days produced significant reductions in body weight gain, decreases in adipose tissue mass, and increases in fat oxidation, with effect sizes comparable to those of full-length human growth hormone [1]

These unique dynamics are globally consistent, suggesting that their levels in human milk are tightly regulated throughout lactation and, consequently, that they might have specific roles in the developing neonate

doi: 10.1139/bcb-2016-0070 107 MorganteGDarinoISpanALuisiSLuddiAPiomboniPet al